Humanized Mouse Models

Humanized mouse models are defined as models in which the mouse gene is replaced with human gene orthologs or regulatory elements. These substitutions can target the whole gene or part of the gene such that specific protein domains are human. The human gene is thus expressed in tissues to replace the mouse gene. These models are valuable in the development and testing of immunotherapy. For human cytokine expression to study the immune reaction and improve engraftment.

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