Genetically engineered mouse models (GEMM) contain a foreign DNA incorporated into their genome. The revolution of genetic modifications in mice first started in 1974 when Rudolf Jaenisch and Beatrice Mintz discovered that DNA injected into mouse embryos could be incorporated into the mouse genome. Transgenic, Knockout, and Knockin mice are the most common type of engineered mice models and are a powerful tool to study human diseases and for drug discovery.
At TME, using state-of-art technology like CRISPR we engineer DNA molecules and microinjected them into fertilized oocytes, and implant them back into the pseudopregnant mice. These mice continued to produce to term offspring containing desired genetic modifications.